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KMID : 0378019890320120051
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New Medical Journal
1989 Volume.32 No. 12 p.51 ~ p.56
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Effect of Cyclobuxine D on the Derangement Induced by Hypoxia in the Isolated Rat Heart
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이종화/Lee, J.H.
문창규/권준택/조병헌/최규홍/김유재/김종배/Moon, C.K./Kwon, J.T./Cho, K.H./Kim, Y.J./Kim, C.B./Kim, C.S.
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Abstract
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Cyclobuxine D is a steroidal alkaloid, which was extracted from Buxus microp ylla var. koreana Nakai. In our previous studies, we clarified several pharmacological effects of cyclobuxine D: an antiinflammatory action; hypotensive and bradycardic effects in rats and inhibition of the transmembrane flux of calcium in potassium-activated calcium chann, ls.
The present study was undertaken to elucidate possible mechanisms by prot: tion of . myocardial cells from hypoxia-induced derangement in cardiac function and meta i .lism by cyclobuxine D. For this purpose, the isolated rat heart was used. Rat hearts were perfused for 20min under hypoxic conditions in the presence and absence of cyclobuxine D . d verapamil, and for 45min under reoxygenated conditions. Hypoxia induced a marked . ecline in contractile force, an immediate release of ATP metabolites and an accumulation of calcium. Cyclobuxine D and verapamil enhanced the recovery of the contractile force, suppr -ssed the rise in resting tension and protected the myocardial cell from calcium accumulation in the hypoxia and subsequent reoxygenation heart.
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